How Long Does Mirtazapine Stay in Your System?

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Andreas Meistad
Jan 5, 20233 min read
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How Long Does Mirtazapine Stay in Your System?

Mirtazapine is a prescription medication that is commonly used to treat depression, anxiety, and sleep disorders. It works by altering the levels of certain chemicals in the brain that can become imbalanced and cause mood disorders. Mirtazapine is generally well-tolerated and effective at reducing symptoms of depression and anxiety, but like all medications, it can have side effects and may interact with other medications. One question that people may have about mirtazapine is how long it stays in the body. In this article, we'll explore the factors that can affect the length of time mirtazapine stays in your system.

  • Dosage: The dosage of mirtazapine that you're taking can affect how long the medication stays in your system. Higher doses of mirtazapine may stay in the body for a longer period of time than lower doses.
  • Metabolism: The speed of your metabolism can affect how long mirtazapine stays in your system. People with a faster metabolism may clear the medication from their body more quickly than those with a slower metabolism.
  • Age: Age can also play a role in how long mirtazapine stays in your system. As we get older, our metabolism tends to slow down, which can cause medications to stay in the body for a longer period of time.
  • Frequency of use: The frequency of your mirtazapine use can also affect how long the medication stays in your system. Taking mirtazapine daily may result in the medication staying in your body for a longer period of time compared to taking it on an as-needed basis.
  • Other medications: If you're taking other medications, they may interact with mirtazapine and affect how long the medication stays in your system. It's important to inform your doctor about all the medications you're taking, including over-the-counter drugs, herbs, and supplements, to avoid potential interactions.

So, how long does mirtazapine typically stay in your system? The answer is that it can vary widely depending on the factors mentioned above. In general, mirtazapine has a half-life of about 20-40 hours, which means it takes about 20-40 hours for the medication to be metabolized and eliminated from the body. However, mirtazapine can be detected in the body for a longer period of time, up to several days or weeks in some cases.

It's important to note that the length of time mirtazapine stays in your system can have implications for drug testing. If you're taking mirtazapine and are concerned about drug testing, you should speak with your doctor about the potential for the medication to show up on a test.

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In summary, the length of time mirtazapine stays in your system can vary depending on factors such as dosage, metabolism, age, frequency of use, and other medications you may be taking. Mirtazapine has a half-life of about 20-40 hours, but it can be detected in the body for a longer period of time. If you're taking mirtazapine and have questions about how long it stays in your system, you should speak with your doctor. They can provide you with more information and guidance based on your individual circumstances.


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Cognitive behavioral therapy for insomnia (CBT-I) is a natural, side-effect-free sleep treatment. It involves relearning your sleep habits and addressing issues that are getting in the way of quality sleep. Studies show that CBT-I works as well as or better than sleep medications and that its effects last after the treatment is done.1

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Andreas Meistad@s profile picture
Andreas Meistad

Therapist specializing in applying CBT principles for the treatment of insomnia.

It’s time to stop blaming the night monsters.

Let’s work together to transform your sleep for the better.