How Long Does Trazodone Last?

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Rahul Shivkumar
Mar 22, 20232 min read

How Long Does Trazodone Last?

Trazodone, an atypical antidepressant, is commonly prescribed off-label for the treatment of insomnia due to its sedating effects. In this section, we will discuss the duration of Trazodone's effects, its half-life, and factors that can influence how long it lasts in the body.

Trazodone's half-life, or the time it takes for the body to eliminate half of the drug, typically ranges from 5 to 9 hours. However, this can vary depending on individual factors such as age, metabolism, liver function, and the presence of other medications. Generally, it takes approximately 5 half-lives for a drug to be fully eliminated from the body, meaning that Trazodone could take anywhere from 25 to 45 hours to be cleared from the system.

The duration of Trazodone's sedative effects can also be influenced by the dosage prescribed. Lower doses tend to have a shorter duration, while higher doses may produce more prolonged effects. For sleep, Trazodone is usually prescribed at a lower dose than when used as an antidepressant. This lower dosage typically results in sedative effects lasting around 6 to 8 hours, making it suitable for promoting a full night's sleep without causing excessive daytime drowsiness.

However, individual responses to Trazodone can vary, and some people may experience lingering drowsiness or other side effects the following day. It is essential for patients to discuss their experiences and concerns with their healthcare provider, who can adjust the dosage or recommend alternative medications if needed.

In summary, the duration of Trazodone's effects depends on factors such as dosage, half-life, and individual metabolism. Generally, the sedative effects of Trazodone can last from 6 to 8 hours, but this may vary among individuals.

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Rahul Shivkumar's profile picture
Rahul Shivkumar

Software Engineer & Sleep Enthusiast

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