Thinking About Doxepin for Sleep?

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Andreas Meistad
Jan 9, 20233 min read
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Thinking About Doxepin for Sleep?

Doxepin is a medication that is commonly used to treat insomnia and other sleep disorders. It is a tricyclic antidepressant, which means it is classified as a type of antidepressant medication that is derived from the chemical structure of the tricyclic group of compounds.

How Does DoxepinWork?

Doxepin works by inhibiting the reuptake of the neurotransmitters serotonin and norepinephrine in the brain, which can help improve mood and reduce anxiety. However, doxepin is also effective at treating insomnia due to its sedative properties.

Are There Benefits of Using Doxepin for Sleep?

One of the main advantages of doxepin for sleep is that it is a non-benzodiazepine medication, which means it is not a member of the class of drugs known as benzodiazepines. Benzodiazepines are commonly used to treat anxiety and insomnia, but they can be habit-forming and may cause side effects such as dizziness, drowsiness, and impaired coordination. In contrast, doxepin is a safe and effective alternative for treating insomnia without the risk of dependence or negative side effects.

Doxepin is available in several different forms, including oral tablets, capsules, and a liquid solution. It is typically taken once a day at bedtime, although the specific dosage and frequency may vary depending on the severity of insomnia and the individual needs of the patient. It is important to follow the instructions of a healthcare provider when taking doxepin and to report any concerns or side effects to a doctor.

Possible Side Effects of Doxepin

Some common side effects of doxepin for sleep may include dry mouth, constipation, and dizziness. These side effects are generally mild and may go away after a few days of treatment. More serious side effects are rare but may include changes in heart rate, difficulty urinating, or allergic reactions. It is important to notify a healthcare provider if any of these side effects occur.

It is also important to be aware of the potential for doxepin to interact with other medications. Doxepin may interact with other antidepressants, antihistamines, and other medications that affect the central nervous system. It is important to inform a healthcare provider about all medications and supplements being taken before starting treatment with doxepin.


Doxepin is a safe and effective treatment option for insomnia and other sleep disorders. It is a non-benzodiazepine medication that is less likely to cause dependence or negative side effects compared to other medications. While it may cause some mild side effects in some individuals, these side effects are usually temporary and can be managed with the guidance of a healthcare provider. If you are experiencing difficulty sleeping, talk to your healthcare provider about whether doxepin may be right for you.

CBT-I: A Long-Term Sleep Fix

Many people choose to use medication to help them get to sleep, however, Doxepin has not been well studied, and its safety and effectiveness aren’t yet understood.

Cognitive behavioral therapy for insomnia (CBT-I) is a natural, side-effect-free sleep treatment. It involves relearning your sleep habits and addressing issues that are getting in the way of quality sleep. Studies show that CBT-I works as well as or better than sleep medications and that its effects last after the treatment is done.1

Fill out Dawn Health’s questionnaire to get started with CBT-I right from your computer — no in-person visits necessary. Quality, natural sleep is possible when you embark on a CBT-I treatment journey.

Andreas Meistad@s profile picture
Andreas Meistad

Therapist specializing in applying CBT principles for the treatment of insomnia.

It’s time to stop blaming the night monsters.

Let’s work together to transform your sleep for the better.